Endocrine Abstracts

The aim of our study is to detect parameters which may predict recurrences during long-term follow-up in papillary thyroid cancer patients who achieved remission after primary treatment. The data of 492 patients who achieved selected remission criteria after primary treatment were recorded. Remission criteria were for anti-thyroglobulin (antiTg)-negative patients: no uptake in first iodine-131 whole body scan (WBS) after primary treatment and stimulated thyroglobulin (Tg) leve...

Introduction: We have reported a case of breast carcinoma complicated by diabetes insipidus due to pituitary metastasis.Case: A 47 years old woman had been referred our clinic with the symptoms of polyuria, polydypsia, weight loss, and fatigue. She had a diagnosis of breast carcinoma for six years, underwent radically mastectomy, chemotherapy and radiotherapy, subsequently. Vertebral metastasis was detected and local radiotherapy was performed six months...

Introduction: Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism and represent <1% of all pituitary adenomas. The majority of TSHomas (70%) secrete TSH alone, while mixed adenomas are not infrequent.Design: Herein, we reported the findings of six patients with TSHoma (mean age 44 yr, 4 female, 2 male). Mean TSH value was 15.1 mIU/L (3.3–38.0) who were followed-up in our department.Result...

A 41-year-old woman was admitted with headache and hypertension. She described worsening of headaches in the last 2 months. On physical examination blood pressure was 150/90 mmHg, and grade 1 hypertensive retinopathy was present. Her sister died at the age of 24 due to pancreas neuroendocrine tumour and her mother was followed up with multiple pancreatic cysts. Abdomen MRI revealed a 6 cm phaeochromocytoma lesion on the right surrenal and multiple cysts in the pancreas, kidney...

Propylthiouracil (PTU) is a widely used drug, and can cause drug-induced vasculitis which is characterized by inflammation and cellular infiltration of small vessels and presence of anti-neutrophil cytoplasmic antibodies (ANCA). We report a case of perinuclear antineutrophil cytoplasmic antibody-associated vasculitis developed during treatment with PTU for Graves’ disease. A 58-year-old woman admitted to the Emergency Department with painful necrotic lesion at her right e...

Clinical spectrum of phaeochromocytoma syndromes are very heterogeneous. Sometimes life threatening hypertensive attacks may be the presenting symptom or the clinical picture may be subtle that a nonspecific symptom like fatigue can lead to diagnosis. We herein present two phaeochromocytoma cases with distinct clinical features.Case 1: A 20-year-old female patient admitted to emergency department with blurred vision and headache. She experienced headache...

Oncogenic osteomalacia is a rare paraneoplastic syndrome, which can be associated with phosphaturic mesenchymal tumor or non-mesenchymal tumour. This tumour produces fibroblast growth factor 23 (FGF-23) that leads to subsequent hypophosphataemic osteomalacia. We, hereby present a patient with oncogenic osteomalasia who is misdiagnosed as ankylosing spondylitis. A 54-year old man with weakness, severe arthralgia involving pelvis, hip joints and lower extremities referred to the...

Aim: Several studies suggested that there is a relationship between serum levels of IGF1 or their polymorhisms and some cancer types. The genetic polymorphism in the region of IGF promoter region which is composed of cytosine–adenine repeats, affects the promoter activity. It is suggested that serum IGF1 levels are inversely associated with the length of CA repeats. There are studies reporting that the carriers of the CA 19 allele are more likely to develop some cancer ty...

Objective: We aimed to investigate the expression of ret/PTC oncogene in PTC and to determine the relationship of this expression with clinical parameters and the prognosis.Materials and methods: Surgical specimens of 45 PTC and adjacent normal thyroid tissues were obtained from the files of the Department of Pathology at Istanbul Faculty of Medicine, Istanbul University. All of the patients had definite diagnosis of PTC between 1995–2003 and had ad...

Introduction: We report a case of paraganglioma of glomus caroticum with lung metastases treated with 150 mCi 131I-MIBG.Case: A 25-year-old woman was referred to our department for cachexia. She had low BMI (18) normotension, mild normochromic normocytic anemia with a mass under left mandibula. Radiologic imaging of neck revealed that 24×36×45 mm diameter mass surrounding of carotis externa and interna at the level of bifurcation. She underwent...